" Between 1999 and 2004, 4,145 patients diagnosed with prostate cancer were enrolled in the database at M.D. Anderson Cancer Center. A total of 100 patients were identified who had disease progression with a PSA level <2ng/ml. Disease progression was defined as metastasis in >1 of the following sites: bone, viscera or retroperitoneal lymph nodes above the aortic bifurcation. Forty-six men, representing 1.1% of all patients who were entered into the database had appropriate criteria for analysis."

" Overall, 10 (22%) had undetectable serum PSA levels and 30 patients (65%) had PSA of <1ng/ml at the time of disease progression. Of the 25 men who had undergone radical prostatectomy, 7 were hormone naïve at the time of progression. The median increase in PSA was 0.25ng/ml at the time of progression. In 19 patients, there was no
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