| " People with a damaged copy of the gene, GAB2, may be at four times increased risk of developing dementia, Neuron journal reports. " " Experts said the latest findings were some of the most significant to emerge since the discovery of the ApoE4 Alzheimer's gene. " " Late-onset Alzheimer's affects one in 10 people over 65 and half of over 85s. " "The results are some of the most significant finds for genetic risk factors since the discovery of ApoE4" " The researchers, from 15 institutions including the Institute of Neurology in London, analysed the DNA of 1,411 people and found GAB2 influenced the risk of dementia among those with APOE4. " " In turn, this leads to the formation of the characteristic protein "tangles" found in the brains of people with Alzheimer's, the researchers told Neuron. " " To explore the gene's role, Dr Eric Reiman and colleagues experimentally "silenced" GAB2 in neurons and
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