"1. I was taking actos and my doctor switched me avandia claiming better and safer results. It's very disappointing to find out I was put at greater risk from the change. Managing diabetes is hard enough without wondering about the medication and if the drug companies told the doctors to push it and if it has an actual benefit to you. This is definitely a wake up call!"

"Hearts sometimes need lots of glucose and when needs arise the body says 'quickly create a substantial increase in blood glucose to feed my heart cells at this time of need' and the body obeys [except, for example, when there is an ANYdrugTREATED state in the bloodstream which can prevent that natural heart-fuelling process [at its time of need] and consequently may forseeably result in?"

"CLUE... imagine You're a racing Driver and always need a 'fuel surge' for your racing car, when overtaking, but today one of your Crew has fitted a 'new' fuel saving device, to your engine, without your understanding how that device works]..."

"Insulin resistance [ie 'conditioned resistance' to a HYPOglycaemic hormone] is a curative process and is common to both type 1 & type 2 Diabetics."

"Insulin resistance protects the body from insulin surges and in particular the especially crucial CNS [brain & spinal cord] from HYPOglycaemia which can result from such insulin surges ... [without insulin resistance an insulin surge simply 'pumps' vital glucose fuel into the liver, fat & muscles and leaves a 'shortfall' for the CNS and some other type of 'fall' can easily result]."

"Since the introduction of GM insulin, in around 1983, insulin resistance became more associated with type 2 diabetes, rather than type 1 diabetes, because type 2 Diabetics [before treatment with GM insulin] usually have an abundance of insulin & C-peptide and their bodies can safely run above normal glucose levels [HYPERglycaemia] in order to exert greater control over their fuel flow and help prevent HYPOglycaemia."

"GM insulin lacks C-peptide. GM insulin often results in HYPOglycaemic unawareness because GM insulin has the capacity to circumvent insulin resistance. For those who chose GM insulin rather than natural and/or pig insulin ... insulin resistance is futile."

"What if there is ZERO reference anywhere in the history of the world that provides Peer reviewed evidence that ANYdrugTREATED is better than UNdrugTREATED for any type 2 Diabetic?"

"In the continued absence of any such reference it it reasonable to suppose that every type 2 Diabetic 'complication' arises as a result of the treatment of the 'insulin resistance' that was actually keeping type 2 Diabetics healthy in the first place."

"Presumably, in respect of 'Who is ultimately responsible for any consequential side effects?' ... such a reference should be producible by a GP or an MD or any other prescribing Physician treating their type 2 Diabetic Patient..."

"The Hippocratic Oath states: "To please no one will I prescribe a deadly drug nor give advice which may cause his death.""

"'... Why some cases of retinopathy worsen when diabetic control improves ... the rate of fall of blood glucose concentration and the accompanying reduction in blood flow have been thought to be the trigger ... This suggestion was supported by the finding of Grunwald et al, who showed a 20% reduction of blood flow when blood glucose concentrations fell from about 15 mmol/l to 8 mmol/l.'"

"Where's the PROOF that type 2 diabetes ['insulin-resistant diabetes'] is anything other than beneficial? [when UNdrugTREATED]; and if that was other than clear..."

"Where's the PROOF, from your Physician, that type 2 diabetes ['insulin-resistant diabetes'] is anything other than beneficial? [when UNdrugTREATED]."

"Transient supernormal glycaemia 'TSG' occurs in every Human Being as a healthy and natural response to acute stress ['adaptative medicine'] â?¦ distributing glucose to nerve cells [without insulin receptors] and preventing 'HYPOs' [the real concern] â?¦ and may well increase HbA1c â?¦ so what? â?¦ when glucose levels surge up for a transient period [and then down again] an above average HgA1c can just as easily be viewed as a marker for a very healthy 'stress adapted' Human Being who has the benefit of being 'insulin-conservative' [ie a criteria for being labelled a 'type 1 Diabetic'] which protects INTRAcellular components of cells [with insulin receptors], from eg glycation of DNA, during periods of chronic stress."

"If type 2 diabetes [UNdrugTREATED] is a health benefit ... as is proposed ... then most healthy People who have been free from diagnosis of 'above the average blood sugar level' would likely be living happy UNdrugTREATED lives with the benefit TSG... So here's an interesting fact about 7 million People who are 'too healthy to notice'..."

"'...The government estimates that more than 21 million Americans over age 20 have above normal blood glucose, but that at least a third don't know they have it...'"

"ie Apparently some 7 million Americans are adaptatively protected from numerous diseases [including cancer & Parkinsons] by way of 'insulin resistance' aka TSG aka HYPERglycaemia aka 'above normal blood sugar' aka diabetes [without even knowing how They are protected]."

"What is the most definitive study which substantiates the benefit of reducing HbA1c in drug/insulin treated acute&chronic 'insulin-resistant diabetes' [Type 2] â?¦ as compared with treatment-free [drug/insulin] acute&chronic 'insulin-resistant diabetes' [ie in a ZERO drug (repeat zero) treatment control Group ie UNdrugTREATED]? {ps please note the word written there says: "zero"} ie completely ignoring HbA1c value variabilityâ?¦"

"... Am seeking any 'Peer reviewed' study that clearly disassociates drug/insulin treatment from any changes in Patient behaviour [eg diet/exercise] and/or categorically proves that drug/insulin treated acute&chronic 'insulin-resistant diabetes' is healthier than doing absolutely nothing ['zero'] ie just accepting the higher HgA1c value and [possibly beneficial] blood glucose value [and likely beneficial "insulin resistance"]; and"

"What is the most definitive study which provides incontrovertible evidence that the apparent insulin receptor mediated down-regulation [in response to: transient supernormal glycaemia 'TSG'] is anything substantially other than a stress-adaptive mechanism of 'local' [on a cell-by-cell basis] intracellular cyto-protection from influx of excessive [blood] circulating glucose [ie homeostasis] eg cardio muscle protective?"

"... It is reasonable to propose that insulin receptor mediated down-regulation 'IRD' [aka "insulin resistance"] is primarily an adaptive [protective/regulatory/beneficial]
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